RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription
نویسندگان
چکیده
منابع مشابه
A bacteriophage transcription regulator inhibits bacterial transcription initiation by σ-factor displacement
Bacteriophages (phages) appropriate essential processes of bacterial hosts to benefit their own development. The multisubunit bacterial RNA polymerase (RNAp) enzyme, which catalyses DNA transcription, is targeted by phage-encoded transcription regulators that selectively modulate its activity. Here, we describe the structural and mechanistic basis for the inhibition of bacterial RNAp by the tra...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2020
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1920747117